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KMID : 0371619990150010077
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Journal of Wonkwang Medical Science
1999 Volume.15 No. 1 p.77 ~ p.81
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A Case of Chronic Neutrophilic Leukenia
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Lee Young-Jin
Choi Yu-Sun
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Abstract
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Chronic neutrophilic leukemia is a rare myeloproliferative disorder and characterizes unusual sustained neutrophilia with splenomegaly but no fever, inflammation, cancer or other cause of neutrophilia. The neutrophilic alkaline phosphatase(NAP), vitamin B_12, uric acid, lactate dehydrogenase(LD), and ferritin are elevated but t(9;22), bcr/abl rearragement are or not noted. The patent was 68 year old male who was subtrochanteric fracture of right femur at 5 days ago. The WBC was 76.8 × 10 exp (9)/L (neutrophil 96.7%, lymphocyte 1.3%, monocyte 1.2%, eosinophil 0.8%), RBC 3.00 × 10 exp (12)/L, hemoglobin 88 g/L, hematocrit 25.6%, and platelet 199 × 10 exp (9)/L at admission. The serum alkaline phosphatase, LD, ferritin, NAP score were elevated but protein, albumin, cholesterol decreased. The WBC(especially neutrophil) were progressively increased number and up to 134.3 × 10 exp (9)/L (neutrophil 96.3 %, 129.3 × 10 exp (9)/L) but no evidences of neutrophilic leukocytosis. The PBS revealed neutrophilic leukocytosis with shift to the left, toxic granules, and some dysgranulopoiesis. He had splenomegaly, no fever and chill. The patient was expired after the 22th admission day.
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KEYWORD
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Chronic neutrophilicleukemia, NAP score
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